方法：1992至2005年期間，2800例成人患者納入了瑞典BARFOT早期RA研究。患者納入研究時和隨訪2年，5年和8年時均登記疾病活動度評分（DAS28），C反應蛋白（CRP），健康評分問卷（HAQ）,類風濕因子（RF），抗CCP抗體，整體健康和疼痛視覺模擬評分（VAS）,EULAR反應和治療方案。2010年，對2102例患者進行問卷調查，調查其生活方式相關指標，包括是否戒煙。
結果：本研究共納入病程小於2年的RA患者1460例。2010年，吸煙的患者占17%。共有127例患者在納入研究後戒煙。在控製了基線時年齡，病程，性別，社會經濟因素，吸煙狀態，RF和DAS28等因素後，納入研究後戒煙與8年時EULAR反應良好負相關(OR 0.44, 95% CI 0.22-0.86, p=0.02)。
結論：在這個大型的瑞典RA患者隊列中，2010年吸煙患者占17%。發生RA後戒煙並不能改變吸煙的RA患者預後不良的結局，但是所有RA患者均應該戒煙，因為吸煙容易使心血管疾病發生風險增加，並且與RA患者的血管炎和皮下結節密切相關。
附原文：Abstract：OBJECTIVE: We studied the effect of stopping smoking on disease activity in patients with RA.METHODS:Between 1992 and 2005, 2,800 adult patients were included in the BARFOT early RA study in Sweden. Disease Activity Score 28 joints (DAS28), C-reactive protein (CRP), Health Assessment Questionnaire (HAQ), rheumatoid factor (RF), anti-CCP, general health and pain visual analog scales (VAS), EULAR response and treatment were registered at inclusion and at follow-up 2, 5 and 8 years. In 2010, a self-completion postal questionnaire was sent to 2,102 patients, enquiring about lifestyle. factors, including cessation of smoking.RESULTS: A total of 1,460 adult RA patients with disease duration ≤2 years were included in this study. Seventeen percent smoked in 2010. In total, 127 patients stopped smoking after inclusion in the study. Smoking cessation after inclusion in the study was negatively associated with EULAR good outcome at 8 years (OR 0.44, 95% CI 0.22-0.86, p=0.02), controlled for age, disease duration, sex, socioeconomic class, smoking status, RF, and DAS28 at inclusion.CONCLUSION:Seventeen percent of the RA patients smoked in 2010 in this large Swedish RA cohort. Stopping smoking after onset of RA did not change the poor prognosis of smokers with RA, but all RA patients need to stop smoking because of the high risk of cardiovascular mortality and morbidity and the association of smoking with vasculitis and noduli in RA.
引自：Andersson ML, Bergman S, S derlin MK. The Effect of Stopping Smoking on Disease Activity in Rheumatoid Arthritis (RA). Data from BARFOT, a Multicenter Study of Early RA. Open Rheumatol J.2012;6:303-309. Epub 2012 Oct 19.
