目的：本研究的目的是為探討絕經前中國SLE患者25羥維生素D (25(OH)VitD)的表達水平及其與代謝綜合征(MS)及其組分異常的關係。

        方法：在這項橫斷麵研究中，共納入113例絕經前SLE患者，並招募了年齡匹配的健康人群作為對照，收集臨床及實驗室資料，包括血清25(OH)VitD表達水平。多變量分析法分析25(OH)VitD與MS及其組分異常的關係。

        結果： 25(OH)VitD缺乏(<20 ng/ml)及MS在絕經前中國SLE患者中普遍存在(分別為24.8% 和 30.1%)。25(OH)VitD、MS及其組分異常之間的相關分析顯示：25(OH)VitD低表達與MS患病率增加有關(OR=0.920，p=0.012)，與高密度脂蛋白水平降低相關(OR=1.059，p=0.033)，與空腹血糖水平升高相關(OR=0.810，p=0.004)。這些相關性在調整年齡、體重指數及與SLE相關的變量後仍存在。

        結論： 25(OH)VitD表達水平與絕經前係統性紅斑狼瘡患者的代謝綜合征及其組分異常有關。

        附原文:

        Abstract：Objective:This study aimed to investigate thestatus of 25-hydroxyvitamin D (25(OH)D) and its association with metabolicsyndrome (MS) and different MS components among premenopausal women withsystemic lupus erythematosus (SLE) in China.

        Patients and methods:Altogether 113 premenopausal women with SLEand the age-matched healthy cohorts wererecruited in this cross-sectional study.Clinical manifestations and laboratory data including serum 25(OH)Dconcentration were collected. A multivariable analysis was performed to analyzethe association of 25(OH)D with MS and its components.

        Results:The prevalence of 25(OH)D deficiency (25(OH)D<20 ng/ml)and MS were common (24.8% and 30.1%,respectively) in premenopausal patientswith SLE in China. Analysis of the association between 25(OH)D, MS and itscomponents demonstrated that the lower level of 25(OH)D was associated with increasedMS prevalence (OR=0.920, p=0.012), a decreased level of high-densitylipoprotein (OR=1.059, p=0.033) and a higher level of fasting glucose(OR=0.810, p=0.004). These associations were still detectible after adjustmentfor age,body mass index and SLE-related variables.

        Conclusion:The level of 25(OH)D is associated with MS and itscomponents in premenopausal women with SLE.

        引自：Wang L M, Zheng Z H, Li T F, et al. 25-hydroxyvitamin D isassociated with metabolic syndrome among premenopausal women with systemiclupus erythematosus in China[J]. Lupus, 2017, 26(4): 403–409.