摘要 ：

我們對係統性紅斑狼瘡與早產進行了一項薈萃分析。在這項研究中，我們研究了

SLE疾病本身的影響，SLE的疾病活動度、腎髒受累及活動性腎炎對早產的影響。檢索在2016年5月20日前發表在Pubmed、Embase、MEDLINE及Cochrane數據庫裏所有相關文獻，共有十一例觀察性病例對照研究和十三項隊列研究符合納入標準。SLE患者合並早產的相對風險(RR)是健康對照組的2.05倍(95%可信區間：1.72–3.32);病情活動SLE患者的相對風險是病情穩定SLE患者的2.98倍(95% 可信區間: 2.32–3.83)。患有狼瘡腎炎的SLE患者合並早產的相對風險是無狼瘡腎炎的SLE患者的1.62倍(95% 可信區間: 1.35–1.95);患有活動性狼瘡腎炎的SLE患者合並早產的相對風險是狼瘡腎炎處於靜止期的SLE患者的1.78倍(95% 可信區間: 1.17–2.70)總之，這項研究在上述結果中發現了顯著的關聯性，而且這種相關性在活動性SLE患者較非活動患者中更為顯著。就SLE疾病本身而言，活動性炎症(如疾病活動)對妊娠的影響可能更為危險。這表明為達到更好的妊娠結局控製疾病活動是非常必要的。

附原文：

We performed a meta-analysis to identify the association between systemic lupus erythematosus(SLE) and preterm birth. In this study, we studied the effects of SLE, SLE disease activity, a history of nephritis and active nephritis on preterm birth. Searches were conducted before 20 May 2016 of PubMed, Embase, Medline and Cochrane Library of literature and article reference lists. Eleven observational case–control studies and thirteen cohort studies met the inclusion criteria. The pooled relative risk (RR) for the riskof preterm birth in SLE patients versus controls was 2.05 (95% confidenceinterval (CI): 1.72–3.32); for active SLE patients versus inactive was 2.98 (95% CI: 2.32–3.83); for SLE patients with a history of lupus nephritis versus those without nephritis it was 1.62 (95% CI: 1.35–1.95); and for SLE patients with active nephritis versus those with quiescent nephritis it was 1.78 (95% CI: 1.17–2.70). In summary, this study identified a significant association in the above results. This association was more significant in active SLE patients versus inactive. With respect to SLE itself, active inflammation(such asdisease activity) may be more hazardous for the management of the pregnancy. This suggests that it is essential to control disease activity in order to achieve a better outcome of SLE pregnancy.

引自：Wei S, Lai K, Yang Z, et al. Systemic lupus erythematosus and risk of preterm birth: a systematic review and meta-analysis of observational studies[J]. Lupus, 2017, (2017) 26, 563–571.