摘要 目的：大動脈炎(TA)是一種通常影響年輕女性的疾病，其特征在於大血管受累的炎症和缺血征象，包括顱外腦動脈。目前中風對TA預後的影響尚未得到很好的評估。

方法：我們對患有至少一次卒中的TA患者進行了回顧性多中心評估，並將其與17名匹配的無神經係統受累的TA患者進行比較。

結果：從126例診斷為大動脈炎患者中最終篩選出17例存在卒中的大動脈炎患者。在診斷時，兩組患者均比較了心血管危險因素。第一腦血管事件是缺血性卒中(N=15)或短暫性腦缺血發作(N=2)。8例患者中卒中發生在大動脈炎診斷後，4例患者卒中發生在頸動脈手術後。隨訪結束時，59%的患者存在神經功能障礙，35%的存在卒中複發，24%的患者存在癲癇發作。

結論：卒中是大動脈炎患者殘疾的主要原因。由於頸內動脈手術後存在腦卒中發生的風險，故此手術需謹慎進行。

附原文：Objectives Takayasu arteritis (TA) is a giant cell arteritis usually affecting young women and characterized by inflammatoryand ischemic signs of large vessel involvement, including extracranial cerebral arteries. The impact of stroke on TAprognosis has not been well evaluated.Methods We performed a retrospective multicenter review of patients with definite TA who experienced at least one strokeand compared the findings to 17 matched patients with TA diagnosis without neurological involvement.Results Seventeen patients (15 women, median age at stroke diagnosis 44 years) receiving a diagnosis of TA and strokebetween 2002 and 2016 in our institution were included, from a cohort of 126 patients suffering from TA (13.5%). At diagnosis,patients from both groups had comparable cardiovascular risk factors. The first cerebrovascular event was ischemicstroke (n = 15) or transient ischemic attack (n = 2). In eight patients, stroke occurred after the TA diagnosis was made. Infour patients, stroke occurred after carotid surgery. At the end of follow-up, 59% of patients had a neurological impairment,35% had a recurrence of stroke, and 24% suffered from epilepsy.Conclusions Stroke is a major cause of disability in TA patients. Internal carotid surgery may be performed with cautionbecause of the risk of stroke after the procedure.

引自：Priscille CoutureCerebrovascular events in Takayasu arteritis: a multicentercase‑controlled studyJournal of Neurology