摘要：世界範圍內，不斷增長的肥胖流行病導致一係列慢性病。最近的流行病學研究表明，肥胖與類風濕性關節炎(RA)發病之間的關聯，特別是在年輕女性中，由此脂肪因子的促炎作用提供了一種解釋性假說。然而，最近的基於臨床和實驗室的研究提供了顯示，微生物組參與RA起始和發展(包括抗瓜氨酸化抗體形成和Th17細胞活化)的新興證據。肥胖和RA相關微生物組的改變可能提供一個合理的聯係來解決肥胖對RA發病機製的影響。本文介紹了微生物組對RA發展的影響 - 在粘膜和關節部位 -以及與肥胖症與RA關聯的相關病理生理機製，以討論該假說並幫助了解肥胖在RA發展中的作用。

附原文：Abstract：Worldwide, the growing obesity pandemiccontributes to a range of chronic diseases. Recent epidemiological studies havesuggested an association between obesity and the development of rheumatoid arthritis(RA), particularly among young women, whereby pro-inflammatory effects ofadipokines provide one explanatory hypothesis. Yet, recent clinical andlaboratory-based studies provide emerging evidence indicating microbiomeinvolvement in RA initiation and development, including anti-citrullinatedantibody formation and Th17 cell activation. Obesity and RA-associatedmicrobiome alteration might provide a plausible link to address the impact ofobesity to RA pathogenesis. The microbiome's influence on RA development - atmucosal as well as articular sites - and relevant pathophysiological mechanismsregarding obesity's association with RA are presented herein to discuss thishypothesis and aid understanding of obesity's role in RA development.

引自：Luo Y,Blackledge WC.Microbiome-based mechanisms hypothesized to initiate obesity-associated rheumatoid arthritis.Obes Rev.2018 Feb 9. doi: 10.1111/obr.12671. [Epub ahead of print]