目的

探討端粒長度與係統性紅斑狼瘡(SLE)的關係。

方法

檢索PubMed和EMBASE數據庫，根據種族、樣本類型、檢測方法和數據類型，對SLE患者和健康對照組的端粒長度進行Meta分析。

結果

最終共納入八項研究，SLE患者472例和健康對照組365例，結果顯示，SLE患者端粒長度明顯低於對照組(SMD = -0.835, 95%可信區間為1.291至-0.380,P=3.3X10-4)。按種族劃分：高加索人群、亞洲人群和混合人群的SLE患者的端粒長度顯著縮短(高加索人群的SMD =0.455, 95%可信區間為0.763 至-0.147,P= 0.004;亞洲人群的SMD =0.887, 95% 可信區間為1.261至-0.513,P= 3.4X10-4; 混合人群的SMD=0.535, 95% 可信區間為0.923至-0.147,P= 0.007).此外，SLE組在全血及外周血單個核細胞(PBMC)中的端粒長度均明顯短於對照組(全血組SMD =0.361,95%可信區間為0.553 至-0.169,P= 2.3X10-4;PBMC 組SMD = 1.546, 95%可信區間為2.583至-0.510,P= 0.003)。在白細胞中也觀察到了類似的趨勢(SMD = 0.699，95%可信區間為1.511至-0.114，P= 0.092)。依據分析方法或數據類型的薈萃分析揭示了類似的關聯。

結論

我們的薈萃分析表明，不論種族、樣本類型或檢測方法，SLE患者端粒長度均顯著縮短。

原 文

Abstract

Objective:We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE).

Methods:PUBMED and EMBASE databases were searched; metaanalyses were performed comparing telomere length in SLE patients and healthy controls,and on SLE patients in subgroups based on ethnicity, sample type, assay method and data type.

Results:Eight studies including 472 SLE patients and 365 controls were ultimatelyselected which showed that telomere length was significantly shorter in the SLE group than in the control group (standardized mean difference (SMD)=-0.835, 95% confidence interval(CI)=1.291 to -0.380, p=3.3X10-4). Stratification by ethnicity showed significantly shortened telomere length in the SLE group in Caucasian, Asian and mixed populations (SMD=0.455, 95% CI=0.763 to -0.147, p=0.004; SMD=0.887, 95% CI=1.261to-0.513, p=3.4X10-4; SMD=0.535, 95% CI=0.923 to-0.147, p=0.007; respectively). Furthermore, telomere length was significantly shorter in the SLE group than in the control group in whole blood and peripheral blood mononuclear cell groups (SMD=0.361, 95% CI=0.553 to-0.169, p=2.3X10-4; SMD=1.546, 95% CI=2.583 to-0.510, p=0.003; respectively); a similar trend was observed in leukocyte groups (SMD=0.699, 95% CI=1.511 to -0.114, p=0.092). Meta-analyses based on assay method or data type revealed similar associations.

Conclusions:Our meta-analysis demonstrated that telomere length was significantly shorter in patients with SLE, regardless of ethnicity, sample type orassay method evaluated.

引自：Lee Y H, Jung J H, Seo Y H, et al. Association between shortened telomere length and systemic lupus erythematosus : a meta-analysis [J] . Lupus, ( 2017 ) 26, 282 – 288

轉自：中國風濕病公眾論壇

翻譯：北醫三院麻貞貞