嚴重過敏性疾病與成功妊娠之間的因果關係目前尚不清楚。此研究旨在評估在特應性疾病(AD)實驗小鼠模型中生殖表現以及對胎盤形成中起關鍵作用的自然殺傷細胞的出現情況。在存在中度皮膚過敏性病變的NC/Nga懷孕小鼠中我們檢測到IgE水平有8.6倍升高。在正常胎兒數目、流產率以及胎盤大小上未檢測到明顯的差異。在特應性疾病小鼠模型的胎盤中幾乎沒有自然殺傷細胞。並且與對照組相比，未成熟的胎盤中有著明顯的降低。這些研究結果表明，雖然沒有妊娠過程，但特應性疾病幹擾子宮自然殺傷細胞的分化並對胎盤的形成有不利影響。上述表現或許可能是在特應性疾病背後特定的免疫條件調控有利於生殖能力的恢複。

附原文

ABSTRACT. The causal relationship between severe allergic conditions and successful pregnancy remains unclear. We aimed to evaluate reproductiveperformance in an experimental mouse model of atopic disease (AD), and the appearance of uterine natural killer (uNK) cells thathave crucial roles in placental formation was examined. In the NC/Nga pregnant mice with moderate skin allergic lesions and an 8.6-foldelevation of plasma IgE, significant differences were not detected in the reproductive indices of the number of normal fetuses, abortion rateand placental size. There were few uNK cells in the placenta of AD mice, and they showed a significant decrease regarding the immaturesubtype as compared with controls. These findings revealed that AD disturbs uNK cell differentiation and provides disadvantageous effectson placental formation, although it does not arrest the pregnancy process. It may be possible that specific immunological conditions behindAD operate favorably to recover the reproductive performance.

引自

Kazuhiko HAYASHI, Ken Takeshi KUSAKABE, Satoko SUGIMOTO

Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cellsdoi: 10.1292/jvms.13-0547; J. Vet. Med. Sci. 76(6): 913–916, 2014.