目的：本研究的目的是在一個規模較大的未分化結締組織病(UCTD)的隊列研究中判斷係統性紅斑狼瘡國際協作組織(SLICC)2012係統性紅斑狼瘡(SLE)分類標準在疾病初期以及長達15年(1999-2013)的隨訪過程中的診斷價值，進而根據美國風濕病學會(ACR)1997和SLICC2012兩個分類標準在判斷其在UCTD至SLE轉變過程中的價值。
方法：本研究納入符合Mosca等製定的UCTD診斷標準的患者。所有患者在診斷初期(T0)以及之後隨訪期間的3個不同的時間點，均應用SLICC2012 SLE分類標準進行重新判斷並與ACR1997標準判斷的結果進行對照。
結果：共納入329例患者。在診斷初期，即T0期，沒有一例患者符合SLE/ACR標準，同期，有44例患者符合SLE/SLICC的SLE分類標準。在整個隨訪期中，另有23例患者符合了SLE/SLICC的分類標準，14例患者符合了ACR分類標準，這部分患者逐步有UCTD進展至SLE。急性或亞急性皮疹、抗磷脂抗體陽性和漿膜炎與進展至SLE呈相關性。
結論：在本UCTD隊列中，在疾病初期應用SLICC-SLE分類標準可以減少部分漏診的SLE病例。在隨訪中，與ACR的分類標準相比，SLICC的分類標準可將部分診斷為UCTD的患者更正為SLE的診斷。
附原文：Abstract：Objectives The objectives of this study were to analysethe performance of theSystemicLupusInternationalCollaborating Clinics (SLICC)2012classificationcriteriaforsystemiclupuserythematosus(SLE)in alargecohortofundifferentiatedconnectivetissuedisease(UCTD)population at onset of thediseaseand duringalong-termfollow-upof 15 years (1999-2013) and to evaluatethe transition from UCTD to SLE, according to American College of Rheumatology(ACR) 1997 andSLICC2012classificationcriteria. MethodsAcohortof patients who mettheclassificationcriteriaproposed by Mosca etal. forUCTD, were analysed.TheSLICC2012classificationcriteriafor SLE wereretrospectively applied to each patient at the time of the diagnosis (T0) and alsoperiodically re-applied and compared to ACR 1997criteriaat threedifferent time points in thefollow-up. Results 329 patients wereenrolled. According to inclusioncriteriaat T0 no patient met the SLE/ACRcriteria,whilst, retrospectively applying the SLE/SLICCcriteria,44 patients already satisfied this set ofcriteriafor SLE. Duringthefollow-up23 new patients reached theSLE/SLICCcriteriaand 14 patients met theACRcriteriawith a stable rate of progression to SLE over time.Acute or subacute skin rash, antiphospholipid antibody (aPL) positivity and serositiswere the variables correlated to theevolutionto SLE. Conclusions Inour UCTD population, the applicationofSLICCclassificationcriteriaforSLE atdiseaseonset allowed identification of a proportion ofotherwise missed SLE cases; duringfollow-up, and compared withACRcriteria,SLICCcriteriaexpanded the number ofpatients classifiable as SLE otherwise classified as UCTD.
引自：Bortoluzzi A,Furini F,Campanaro F,Govoni M.ApplicationofSLICCclassificationcriteriainundifferentiatedconnectivetissuediseaseandevolutioninsystemiclupuserythematosus:analysisofalargemonocentriccohortwithalong-termfollow-up.Lupus.2017 May;26(6):616-622.
