目的：白介素33（IL-33）是IL-1家族的成員和孤兒受體ST2的配體，在先天和適應性免疫中起關鍵作用。我們調查了IL-33 / ST2水平與活動性成年Still病（AOSD）患者臨床表現之間的關係。
方法：從40例活動性AOSD患者，28例類風濕關節炎患者（RA）和27例健康對照（HC）中收集血樣。使用ELISA方法測定IL-33和可溶性ST2的血清水平。從34例存在皮疹的AOSD患者中獲得活檢標本，通過免疫組織化學研究IL-33和ST2的表達水平。
結果：AOSD患者的IL-33水平高於RA和HC患者。 AOSD患者的可溶性ST2水平高於HC，而非RA患者。血清IL-33水平與全身評分，紅細胞沉降率，鐵蛋白水平和天冬氨酸轉氨酶水平相關。然而，血清可溶性ST2水平僅與鐵蛋白水平相關。與HC相比，AOSD患者的皮損中表達IL-33和ST2的炎性細胞數量升高，但與濕疹或牛皮癬皮損處細胞表達沒有差異。
結論：我們發現活動性AOSD患者的血清IL-33和可溶性ST2水平顯著升高。結果表明IL-33 / ST2信號通路可能在AOSD相關的急性炎症和皮膚表現的發病機製發揮作用。
附原文：
OBJECTIVE: Interleukin 33 (IL-33), a member of the IL-1 family and a ligand of the orphan receptor ST2, plays key roles in innate and adaptive immunity. We examined the associations between IL-33/ST2 levels and clinical manifestations of patients with active adult-onset Still's disease (AOSD).
METHODS: Blood samples were collected from 40 patients with active AOSD, 28 patients with rheumatoid arthritis (RA), and 27 healthy controls (HC). The serum levels of IL-33 and soluble ST2 were determined using ELISA. Expression levels of IL-33 and ST2 in biopsy specimens obtained from 34 AOSD patients with rash were immunohistochemically investigated.
RESULTS:IL-33 levels of patients with AOSD were higher than those of patients with RA and HC. Soluble ST2 levels of patients with AOSD were higher than those of HC, but not of patients with RA. Serum IL-33 levels correlated with systemic score, erythrocyte sedimentation rate, ferritin levels, and aspartate transaminase levels. However, serum soluble ST2 levels correlated only with ferritin levels. The numbers of inflammatory cells expressing IL-33 and ST2 were elevated in skin lesions of patients with AOSD compared to HC, but did not differ from those of the skin lesions of eczema or psoriasis.
CONCLUSION:We found significantly higher serum IL-33 and soluble ST2 levels in patients with active AOSD. Results indicate that the IL-33/ST2 signaling pathway may play a role in the pathogenesis of the acute inflammation and skin manifestations associated with AOSD.
引自：Han JH1, Suh CH1, Jung JY1,et al.Serum Levels of Interleukin 33 and Soluble ST2 Are Associated with the Extent of Disease Activity and Cutaneous Manifestations in Patients with Active Adult-onset Still's Disease.Rheumatol. 2017 Apr 1. pii: jrheum.170020. doi: 10.3899/jrheum.170020. [Epub ahead of print]
