目的：根據中國SLE治療研究組（CSTAR）數據庫的大型隊列研究中國係統性紅斑狼瘡（SLE）患者漿膜炎的患病率和臨床特征。
方法：根據CSTAR的數據進行了SLE患者的前瞻性橫斷麵研究。 漿膜炎定義依據1999年修訂的美國風濕病學會（ACR）SLE標準，即通過超聲心動圖，胸部X線檢查或胸部電腦斷層掃描（CT）掃描檢測到胸膜炎/胸腔積液和/或心包炎/心包積液。腹膜炎/腹膜積液通過腹部超聲檢查證實。我們分析了漿膜炎的患病率和臨床與人口學數據，器官受累情況，實驗室檢查和SLE疾病活動的關係。
結果：在2104例SLE患者中，345例診斷為漿膜炎。狼瘡性腎炎（LN），間質性肺病和肺動脈高壓的患病率，以及白細胞減少症，血小板減少症，低補體血症和抗dsDNA抗體的患病率顯著高於漿膜炎患者（P <0.05）。 與沒有漿膜炎的患者相比，漿膜炎患者的SLE疾病活動評分顯著升高（P <0.05）。 狼瘡相關腹膜炎具有與SLE引起的漿膜炎相似的臨床表現和實驗室特征。
結論：腎病，間質性肺病，肺動脈高壓，低補體血症，白細胞減少症，血小板減少症和升高的抗dsDNA抗體與漿膜炎有顯著的關聯。 結果表明，較高的SLE疾病活動與漿膜炎發展相關，應積極治療。
附原文：
OBJECTIVE:To investigate both the prevalence and clinical characteristics of serositis in Chinese patients with systemic lupus erythematosus (SLE) in a large cohort in the Chinese SLE Treatment and Research group (CSTAR) database.
METHODS: A prospective cross-sectional study of patients with SLE was conducted based on the data from the CSTAR registry. Serositis was defined according to the 1999 revised American College of Rheumatology (ACR) criteria for SLE - that is, pleuritis/pleural effusion and/or pericarditis/pericardial effusion detected by echocardiography, chest X-ray or chest computerized tomography (CT) scan. Peritonitis/peritoneal effusion were confirmed by abdominal ultrasonography. We analysed the prevalence and clinical associations of serositis with demographic data, organ involvements, laboratory findings and SLE disease activity.
RESULTS:Of 2104 patients with SLE, 345 were diagnosed with serositis. The prevalence of lupus nephritis (LN), interstitial lung disease and pulmonary arterial hypertension, as well as the presence of leukocytopenia, thrombocytopenia, hypocomplementemia and anti-dsDNA antibodies was significantly higher in patients with serositis (P < 0.05). Significantly higher SLE disease activity scores were found in patients with serositis compared to those patients without serositis (P < 0.05). Lupus-related peritonitis had similar clinical manifestations and laboratory profiles as serositis caused by SLE.
CONCLUSION:There is a significant association of nephropathy, interstitial lung disease, pulmonary arterial hypertension, hypocomplementemia, leukocytopenia, thrombocytopenia and elevated anti-dsDNA antibodies with serositis. The results suggest that higher SLE disease activity contributes to serositis development, and should be treated aggressively.
