Rheumatology今日在線發布了一項新研究：統計顯示，服用非甾體抗炎藥（NSAID）的患者患上靜脈血栓栓塞（包括深靜脈血栓栓塞和肺栓塞）的風險顯著提高。鑒於目前普通民眾盛行服用非甾體抗炎藥的情況，這一研究對公共衛生具有相當重要的影響。

原文標題：Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis

原文鏈接：http://rheumatology.oxfordjournals.org/content/early/2014/09/22/rheumatology.keu408.full

作者：Patompong Ungprasert、Narat Srivali、Karn Wijarnpreecha、Prangthip Charoenpong、Eric L. Knight

Abstract

Objective. The aim of this study was to integrate and examine the association between NSAID use and venous thromboembolism (VTE).

Methods. We conducted a systematic review and meta-analysis of studies that reported odds ratios, relative risks, hazard ratios or standardized incidence ratios for VTE among NSAID users compared with non-users. Pooled risk ratios and 95% CIs were calculated using a random effects generic inverse variance model.

Results. Six studies with 21 401 VTE events were identified and included in the data analysis. The pooled risk ratio of VTE in NSAID users was 1.80 (95% CI 1.28, 2.52).

Conclusion. Our study demonstrated a statistically significant increased risk of VTE among NSAID users. This finding has important public health implications given the prevalence of NSAID use in the general population.