如果你仔細觀察一下你吃得東西，再認真想想，你就會發現這些東西對機體的膽固醇水平、血壓、血糖並沒有帶來任何改善，那麼該怎麼辦呢？近日，一項發表在TheFASEBJournal雜誌上的研究論文中，來自奧克蘭兒童醫院的研究人員通過研究表示，維生素和礦物質缺失所有發的炎症或許是罪魁禍首，在某些個體中，當營養物的缺失及時糾正後，其機體的健康標誌物就會得到明顯改善。
研究者Bruce Ames博士說道，我們都知道糟糕的飲食習慣會增加疾病風險，但很顯然這並不是一個足夠信服的理由來督促我們改善飲食習慣；然而一種相對容易的幹預措施比如一塊營養棒或許會幫助人們意識到每天食物中足夠的營養對機體的正向影響。
文章中研究者進行了三項臨床試驗，他們讓成年個體每天食用兩塊營養棒，持續2個月，參與者以自身作為對照，隨後研究者在兩個月的時間段內對每一位個體進行研究，測定並記錄個體機體的生化指標和物理性指標，生化指標比如胰島素、低密度脂蛋白水平和高密度脂蛋白水平，物理性指標比如血壓和體重等。
過重或肥胖個體更應該傾向於健康的代謝飲食方式，某些個體可能會通過少食、低熱量等方式來控製降低體重。最後雜誌主編Gerald Weissmann博士說道，如果變得健康就好象減肥或保持身材那樣簡單，那麼生活在極其缺乏食物環境下的祖先或許會與我們同在。這項研究闡明了我們所吃食物的重要性，這對於維持機體健康，抵禦疾病的風險或將非常重要。
doi:10.1096/fj.15-271833
PMC:
PMID:
A multicomponent nutrient bar promotes weight loss and improves dyslipidemia andinsulinresistance in the overweight/obese: chronic inflammation blunts these improvements.
Joyce C. McCann*,1, Mark K. Shigenaga*,1, Michele L. Mietus-Snyder*, , Ashutosh Lal*, Jung H. Suh*, Ronald M. Krauss*, Ginny L. Gildengorin*, Alisa M. Goldrich*, Devan S. Block*, Swapna V. Shenvi*, Tara H. McHugh , Don A. Olson and Bruce N. Ames*
This study determined if twice-daily consumption of a nutrient-dense bar intended to fill gaps in Western diets, without other dietary/lifestyle requirements, favorably shifted metabolic/anthropometric indicators of dysregulation in a healthy direction. Three 8-wk clinical trials in 43 healthy lean and overweight/obese (OW/OB) adults, who served as their own controls, were pooled for analysis. In less inflamed OW/OB [high-sensitivity C-reactive protein (hsCRP) <1.5], statistically significant decreases occurred in weight ( 1.1 ± 0.5 kg), waist circumference ( 3.1 ± 1.4 cm), diastolic blood pressure ( 4.1 ± 1.6 mmHg), heart rate [HR; 4.0 ± 1.7 beats per minute (bpm)], triglycerides ( 72 ± 38.2 mg/dl), insulin resistance (homeostatic model of insulin resistance) ( 0.72 ± 0.3), and insulin ( 2.8 ± 1.3 mU/L); an increase in HDL-2b (+303 ± 116nM) and realignment of LDL lipid subfractions toward a less atherogenic profile [decreased small LDL IIIb ( 44 ± 23.5 nM), LDL IIIa ( 99 ± 43.7 nM), and increased large LDL I (+66 ± 28.0 nM)]. In the more inflamed OW/OB (hsCRP >1.5), inflammation was reduced at 2 wk ( 0.66 mg/L), and HR at 8 wk ( 3.4 ± 1.3 bpm). The large HDL subfraction (10.5–14.5 nm) increased at 8 wk (+346 ± 126 nM). Metabolic improvements were also observed in lean participants. Thus, favorable changes in measures of cardiovascular health, insulin resistance, inflammation, and obesity were initiated within 8 wk in the OW/OB by replacing deficiencies in Western diets without requiring other dietary or lifestyle modifications; chronic inflammation blunted most improvements.—McCann, J. C., Shigenaga, M. K., Mietus-Snyder, M. L., Lal, A., Suh, J. H., Krauss, R. M., Gildengorin, G. L., Goldrich, A. M., Block, D. S., Shenvi, S. V., McHugh, T. H., Olson, D. A., Ames, B. N. A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements.
