Abstract: To compare the remission of type 2 diabetes mellitus(T2DM) through treatment with laparoscopic sleeve gastrectomy(LSG) or laparoscopic Roux-en-Y gastric bypass (LRYGB), and toanalyze the cost-effectiveness of medical treatment, LSG, and LRYGBin T2DM patients (BMI28).

A 2-group randomized controlled trial was conducted at DiabetesSurgeryCentre, Beijing Shijitan Hospital inBeijing, China. Subjectswere 80 patients ages 16 to 65 years with a body mass index of 28 kg/m2or more and duration of T2DM no more than 15 years. Subjects wererandomly assigned (1:1) to undergo either LSG (n=40) orLRYGB(n=40) between February 3, 2011 and October 31, 2013. Of thosepatients, 72 (90%) were available at follow-up at 2 years. These patientsincluded 34 (85%) who underwent LSG and 38 (95%) who underwentLRYGB. This study presents the follow-up data at 2 years, whichcompared LSG and LRYGB in T2DM patients. Partial remission andcomplete remission were determined, and weight loss, BMI, changes inabdominal circumference, cholesterol, and triglycerides were measured.The cost-effectiveness of each type ofBariatricsurgery was analyzedwith a Markov simulation model that yielded quality-adjusted life-years(QALYs) and costs.

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